Prasanna , B. A Green and Efficient Protocol for the Synthesis of Quinoxaline, Benzoxazole and Benzimidazole Derivatives Using Heteropolyanion-Based Ionic Liquids: As a Recyclable Solid Catalyst. ZnO-beta zeolite mediated simple and efficient method for the one-pot synthesis of quinoxaline derivatives at room temperature Determination of ultra-trace amounts of inorganic selenium species in natural water by ion chromatography-inductively coupled plasma-mass spectrometry coupled with nano-Al2O3 solid phase extraction. - Up-scaling of the process developed in the lab to pilot plant and the desired quality and yield of the product. , 2014, Advance Article. et al evaluated for in vitro efficacies of the 1,4-di-N-oxide quinoxaline derivatives against Mycobacterium tuberculosis and has lead to the discovery of a derivative with in vivo efficacy in the mouse model of tuberculosis24. ir Abstract Efficient syntheses of quinoxalines from the reaction of a-hydroxy ketones and o- phenylenediamine in acetic acid via two methods, a thermal procedure. Results and Discussion The required cyclization precursors 1, aryl substituted (1H-. Abstract: A simple and efficient protocol has been developed for the synthesis of quinoxalines. 2005 , 46 , 7183-7186. PRASANNA*, B. , Bridged) (e. Chemical Methodologies , 1(Issue 1. pdf), Text File (. synthesis of quinoxaline derivatives via condensation of aryl-1,2-diamines with 1,2-diketones using (nh4)6mo7o24. In summary, we have developed an efficient method for the synthesis of quinoxaline derivatives via the condensation of 1,2-diamines with α-diketones. Compared with the classical synthetic method, this new method. The reaction of 1,2-diketone and 1,2-diaminobenzene derivative was carried out in water at room temperature using 10 mol% of task-specific dicationic. The catalyst has the advantage of Lewis as well as Bronsted acidity and recyclability without significant loss in catalytic activity. The synthesis of quinoxaline and phenazine derivatives using MgSO4·7H2O as a catalyst. Burguete A, Pontiki E, Hadjipavlou-Litina D, Ancizu S, Villar R, Solano B, Moreno E, Torres E, Pérez S, Aldana I, Monge A (2011) Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents. The one-pot cascade process involves the acidic elimination of α-aminoxylated dicarbonyl compounds to generate 1,2,3-tricarbonyl compounds and subsequent condensation with 1,4-N,N or -N,O dinucleophiles to afford quinoxaline, pyrazine. Results and Discussion The required cyclization precursors 1, aryl substituted (1H-. , Badadhe P. Optimal method were developed for the green synthesis of quinoxaline derivatives based on the highly efficient and simple condensation reaction of various aromatic 1,2-diketones and 1,2-diamines. synthesis of quinoxaline derivatives from 2-chloro quinoxaline and different types of amine derivatives using PEG-400 green solvent at room temperature. Romanelli 3 , *. An efficient synthesis of the potential pharmacophore 1,4 -dihydro -quinoxaline -2,3 -dione (1) has been achieved in a one-pot reaction at room temperature from substituted o-phenylene diamine and oxalic acid under solvent -free conditions by a simple grinding method with unsurpassed atom economy. well as being important in human health and as receptor antagonists. [10,11] In addition, quinoxaline derivatives are reported for their application in dyes, efficient electroluminescent materials, organic semiconductors and DNA cleaving agents [12]. Synthesis and antimicrobial activity of some new quinoxaline derivatives Subba Rami Reddy SR*, Suryanarayana Rao. Page 280 One-pot and efficient protocol for synthesis of quinoxaline derivatives Mohammad Reza Islami* and Zahra Hassani Department of Chemistry, Shahid Bahonar University, Kerman, Iran P. A Highly Efficient Bismuth Salts-Catalyzed Route for the Synthesis of α-Aminophosphonates: Highly Efficient and Reusable Copper-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles with Aryl Halides: A green and efficient synthesis of quinoxaline derivatives catalyzed by 1-n-butyl-3-methylimmidazolium tetrafluoroborate. The catalyst is efficient and recoverable,but the reaction requires an oxygen atmosphere,and the catalytic efficiency decreases significantly upon reuse. synthetic organic chemistry, there has been tremendous interest in developing efficient methods for the synthesis of quinoxalines. Quinoxaline as a potent heterocyclic… 22 11. A luminescent materials including donor-acceptor compounds with a nitrogen containing donor connected to the 1-position of a carbazole and triazene acceptor connected at the 9-position is disclosed. 2,3&7 In addition, quinoxaline derivatives have also found applications in efficient electron luminescent materials,8 organic semiconductors,9 chemically controllable switches,10 building blocks for the synthesis of anion receptors,11 cavitands12 and. Our research toward the expansion of efficient and environmentally benign synthetis methodologies using eco-friendly conditions[30], we report here the synthesis of quinoxalines from o-phenylenediamine and various α-diketones in the presence. Recyclable Zinc (II) Ionic Liquid Catalyzed Synthesis of Quinoxaline by Direct Condensation of Phenacyl Bromide and o-Phenylene Diamines at Room Temperature - Free download as PDF File (. Conclusions In conclusion, a reliable, rapid and eco-friendly method for synthesis of quinoxalines has been. 2,3&7 In addition, quinoxaline derivatives have also found applications in efficient electron luminescent materials,8 organic semiconductors,9 chemically controllable switches,10 building blocks for the synthesis of anion receptors,11 cavitands12 and. extremely neglected disease which threatens 100 million people, eighteen new quinoxaline 1,4-di-Noxide derivatives have been synthesized following the Beirut reaction. An Efficient Synthesis of Thiazolo and Thiadiazolo Quinoxaline Derivatives in Ionic Liquid B. The one-pot cascade process involves the acidic elimination of α-aminoxylated dicarbonyl compounds to generate 1,2,3-tricarbonyl compounds and subsequent condensation with 1,4-N,N or -N,O dinucleophiles to afford quinoxaline, pyrazine. Synthesis and Biological Activity of Azine Heterocycle Functionalized Quaternary Phosphonium salts Patil Akshay Ravindra and S Karpagam Department of Chemistry, School of Advanced Sciences, VIT University, Vellore. Sami Sajjadifar et al. , 2014, Advance Article. N2 - Cupric sulfate pentahydrate is an efficient catalyst for a one-pot synthesis of quinoxaline derivatives. 9% and luminance of 16760 cd m-2. Quinoxaline. Huang et al found Keggin type heteropolyacids to be an efficient and reusable catalyst for the synthesis of biologically active quinoxaline derivatives from the condensation of 1,2-diamine with 1,2-dicarbonyl. JAGANNADHAM and SUMANGALA RAO Research Centre, Department of Chemistry Chaitanya PG College, Warangal-506 001, India [email protected] Bhusareb and Rajendra P. This substructure plays an important role as a basic skeleton for the design of a number of. The ipsilateral local peripheral (10-300 μg/paw) and intrathecal (100 μg/rat) administration of 1 produced a reduction in formalin-induced nociception. The substrate was treated with TBN and the additive tetra-n-butylam-monium bromide (TBAB) in MeCN at 608C. The reaction can be performing in water as well as ethanol. have investigated the synthesis of quinoxalines in the presence of heteropoly acid at room temperature. Synthesis and antimicrobial activity of some new quinoxaline derivatives Subba Rami Reddy SR*, Suryanarayana Rao. As a part of our ongoing program to develop the application of catalyst-free techniques in organic synthesis,15,16 herein, an efficient, green and simple catalyst-free method for the synthesis of quinoxaline derivatives from. Isopropylidenation of 4-chloro-4-deoxy-α-d-galactose with 2,2-dimethoxypropane, followed by selective hydrolysis, afforded 2,3-O-isopropylidene-4-chloro-4-deoxy-d-galactose di-methyl acetal (3) as a sole product. Efficient ligand exhibiting high levels of enantiocontrol in synthetic transformations ranging from metal-catalyzed 1,4-addition of arylboronic acids to alkylative ring opening to asymmetric hydrogenation. The direct conversion of α-hydroxy ketones and α-keto oximes into quinoxaline derivatives in the presence of a catalytic amount of ceric ammonium nitrate via metal-catalyzed aerobic oxidation followed by in situ trapping with aromatic 1,2-diamines in water as a green and efficient reaction media, is reported. Synthesis and application of thiadiazoloquinoxaline-containing chromophores as dopants for efficient near-infrared organic light-emitting diodes. , & Wang, Z. A precursor strategy for the synthesis of low band-gap polymers: An efficient route to a series of near-infrared electrochromic polymers. An efficient and facile synthesis of quinoxaline derivatives catalyzed by KHSO 4 at room temperature Hossein A. Collaboration in an interdisciplinary and international team for "European Cooperation in Science and Technology (COST) - COST 2013-3". Quinoxaline. - Up-scaling of the process developed in the lab to pilot plant and the desired quality and yield of the product. EFFICIENT CATALYST FOR THE SYNTHESIS OF QUINOXALINE DERIVATIVES IN TAP-WATER UNDER SONICATION Anshu Dandia,[a]* Ruby Singh,[a] Jyoti Joshi[b] and Shuchi Maheshwari[b] Keywords: Magnetically separable nanoparticles, quinoxaline derivatives, one-pot synthesis, ultrasound irradiation. Zirconium tetrakis (dodecyl sulfate)[Zr (DS) 4] as an efficient lewis acid-surfactant combined catalyst for the synthesis of quinoxaline derivatives in aqueous media A Hasaninejad, A Zare, MA Zolfigol, M Shekouhy. Simple and efficient synthetic procedures for the preparation of quinoxaline, pyrazine, pyridopyrazine, and benzoxazin-2-one derivatives were developed. Ligand efficiency indexes and predicted toxicity analysis revealed an excellent intrinsic quality of 1. Box 76169-133 E-mail: [email protected] These catalysts were prepared by incipient wetness impregnation. Pharm research project based on lead modification and testing for its biological activity. Page 280 One-pot and efficient protocol for synthesis of quinoxaline derivatives Mohammad Reza Islami* and Zahra Hassani Department of Chemistry, Shahid Bahonar University, Kerman, Iran P. In the synthesis, the reaction of 1,2-phenylenediamines and phenacyl bromide were carried out using pyridine as a catalyst in THF at room temperature to give quinoxalines. Compared with the classical synthetic method, this new method. V and Subba Narayana Kanchana Department of Chemistry, Sri Krishnadevaraya University, Anantapur, AP, India _____ ABSTRACT Quinoxaline derivatives have several pharmaceutical applications. Sarda,a Suresh S. photosensitizers to broaden the active area of diaryliodonium salts. Iranian Journal of Chemistry and Chemical Engineering (IJCCE) , 32, 3, 2013, 61-67. The catalyst has the advantage of Lewis as well as Bronsted acidity and recyclability without significant loss in catalytic activity. ir Abstract Efficient syntheses of quinoxalines from the reaction of α-hydroxy ketones and o-. High yields, relatively short reaction times, efficiency, generality, clean process, simple methodology, low cost, easy work-up, ease of preparation and regeneration of the catalyst and green conditions (in the synthesis of the quinoxaline derivatives) are advantages of the application of [Mesi]Cl as catalyst in the above organic reactions. Medicinal uses of banana (Musa paradisiaca) Biodegradable plastic production from corn starch; Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation; Extractio. In addition, the electronic properties of the versatile starting compound were computed. Efficient Synthesis of Quinoxaline Derivatives Catalyzed by p-Toluenesulfonic Acid Under Solvent-Free Conditions Da-Qing Shi Key Laboratory of Organic Synthesis of Jiangsu Province, Suzhou University, College of Chemistry and Chemical Engineering , Suzhou, China ; College of Chemistry and Chemical Engineering, Xuzhou Normal University , Xuzhou. A simple three-component one-pot approach was developed to generate three novel highly rigid quinoxaline-based sensitizers in DSSCs. Synthesis and design of novel pteridine, quinoxaline and boron compounds with higher biological activity in Drug Discovery processed under industry methodology and SOP operation. Box 76169-133 E-mail: [email protected] Kiran Ga*, Laxminarayana Eb, Thirumala Chary Mc and Ravinder Ma. An efficient total synthesis of (S)-14-azacamptothecin has been accomplished in 10 steps and 56% overall yield from 5H-pyrano[4,3-d]pyrimidine 8. Jagannadham , and Sumangala Rao Research Centre, Department of Chemistry, Chaitanya PG College, Warangal-506 001, India. An efficient synthesis of the potential pharmacophore 1,4 -dihydro -quinoxaline -2,3 -dione (1) has been achieved in a one-pot reaction at room temperature from substituted o-phenylene diamine and oxalic acid under solvent -free conditions by a simple grinding method with unsurpassed atom economy. Bhusareb and Rajendra P. effective, economical nature, easy to handle and it is a step toward green synthesis [3]-[5]. The inventive compounds are of general formula (I), and their pharmaceutically acceptable salts. com Received 21 July 2011; Accepted 5 September 2011. Synthesis and application of thiadiazoloquinoxaline-containing chromophores as dopants for efficient near-infrared organic light-emitting diodes. BibTeX @MISC{Ruiz11thecientificworldjournal, author = {Diego M. Pawara,* a Organic Chemistry Synthesis Lab. 12 3 IBX , HOAc RT R R O O N N R1 R R NH2NH2R1 + Scheme 1 Results and Discussion Very recently we have developed a convenient and efficient procedure for synthesis of quinoxaline derivatives using cupric sulfate pentahydrate as catalyst. Sami Sajjadifar et al. Journal of the Electrochemical Society. Synthesis of Quinoxaline Derivatives using Sulfonic Acid Functionalized Imidazolium Salts as Highly Efficient and Reusable Bronsted Acidic Ionic Liquids Catalysts under Solvent-free Conditions SAMI SAJJADIFAR*, ESHAGH REZAEE NEZHAD and EHSAN KHOSRAVANI Department of Chemistry, Payame Noor University, P O Box 19395-4697, Tehran, Iran. Sajjadifar H. Andriamitantsoa, a Jingjing Wang, a Wenjun Dong, a Hongyi Gao, a Ge Wang *a a Beijing Key Laboratory of Function Materials for Molecule & Structure Construction, School. model substrate and the efficiency of formation of quinoxaline 3aa was examined. Huang et al found Keggin type heteropolyacids to be an efficient and reusable catalyst for the synthesis of biologically active quinoxaline derivatives from the condensation of 1,2-diamine with 1,2-dicarbonyl. An Efficient and Recyclable Nanoparticle-Supported Cobalt Catalyst for Quinoxaline Synthesis. Efficient synthesis of novel 1,2,3-triazole-linked quinoxaline scaffold via copper-catalyzed click reactions Ali Keivanloo٭a, Mohammad Bakherada, Fateme Abbasia, Tayebeh Besharati-Seidani a, Amir Hossein Amina Characterization data and IR, 1H NMR and 13C NMR spectra of the title compounds: [a] School of Chemistry, Shahrood University of. An Alternative Approach to the Synthesis of New Pyrimido[5′,4′:5,6][1,4] Thiazino[2,3-B]Quinoxaline Derivatives Mehdi Bakavoli, Hosein Eshghi, Hamid Azizollahi, Sattar Saberi, and Marziyeh Akbarzadeh. The room temperature ionic liquid 1-n-butyl-3-methylimmidazolium tetrafluoroborate ([bmim]BF4) was used to promote the synthesis of quinoxaline derivatives under grinding condition. efficient after the fourth run (Table 5). Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) with pore size 6 nm was proved to be an efficient heterogeneous nanoporous solid acid catalyst in the synthesis of quinoxaline derivatives from the reaction of o-Phenylenediamines with 1, 2-diketone compounds in very good yields. Both 1,5-benzodiazepine and quinoxaline derivatives are important heterocycles in pharmaceuticals. The room temperature ionic liquid 1-n-butyl-3-methylimmidazolium tetrafluoroborate ([bmim]BF4) was used to promote the synthesis of quinoxaline derivatives under grinding condition. The primarily goals of the development work were to improve the overall yield of the process, to minimize the use of environmentally unacceptable materials, and to obtain a material with a high level of purity. Quinoxaline derivatives are well known in the pharmaceutical industry and have. As a continuation of our research and with the aim of obtaining new antibacterial agents which can improve the current chemotherapeutic antibacterial treatments, a series of quinoxaline-1,4-di-N-oxide derivatives were synthesized and evaluated for antibacterial activity against bacterial growing in macrophages in vitro. Easily synthesized1-methyl-3- (2-oxyethyl) -1H-imidazol-3-ium-borate sulfonic acid {[MOEI] -BSA} as a novel catalyst efficiently promoted the synthesis of quinoxaline derivatives via condensation of various diamines with 1, 2-dicarbonyl compounds at room temperature conditions in ethanol. Synthesis and design of novel pteridine, quinoxaline and boron compounds with higher biological activity in Drug Discovery processed under industry methodology and SOP operation. ChemTech Res. An Efficient Green Synthesis of Quinoxaline Derivatives Using Carbon-Doped MoO 3-TiO 2 as a Heterogeneous Catalyst. Jaso A, Zarranz B, Aldana I and Monge A (2005). et al evaluated for in vitro efficacies of the 1,4-di-N-oxide quinoxaline derivatives against Mycobacterium tuberculosis and has lead to the discovery of a derivative with in vivo efficacy in the mouse model of tuberculosis24. An efficient protocol for the synthesis of quinoxaline derivatives at room temperature using recyclable alumina-supported heteropolyoxometalates Autores: Ruiz, Diego Manuel | Autino, Juan Carlos | Quaranta, Nancy | Vázquez, Patricia Graciela | Romanelli, Gustavo Pablo. Avval and M. Both 1,5-benzodiazepine and quinoxaline derivatives are important heterocycles in pharmaceuticals. An efficient and eco-friendly method have been developed for the synthesis of coupled quinoxaline derivatives via the condensation of diaryl halides with phase transfer catalyst using suitable solvent. An Efficient Protocol for the Synthesis of Quinoxaline Derivatives at Room Temperature Using Recyclable Alumina-Supported Heteropolyoxometalates. 1039/C4GC01316F. This new strategy has several advantages, such as excellent yield, mild reaction conditions, short duration of reaction time, low cost, simple experimental as well as isolation procedures, and. Journal of Industrial and Engineering Chemistry. com Received 21 July 2011; Accepted 5 September 2011. Jadhav,a Sudhakar R. The objective of present research work is to provide green technique for synthesis of quinoxaline derivative. SiO2 and H3PW12O40 in high yields and short reaction times, and at room temperature is introduced. magnetically separable cufe2o4 nanoparticles: an efficient catalyst for the synthesis of quinoxaline derivatives in tap-water under sonication A simple and rapid synthetic methodology has been explored exhibiting the use of a magnetically separable copper ferrite (CuFe 2 O 4 ) nanocatalyst in water for the construction of medicinally privileged. Results and Discussion The required cyclization precursors 1, aryl substituted (1H-. Using this method, quinoxaline derivatives as biologically interesting compounds are produced in high to excellent yields and short reaction times. Pawara,* a Organic Chemistry Synthesis Lab. An Alternative Approach to the Synthesis of New Pyrimido[5′,4′:5,6][1,4] Thiazino[2,3-B]Quinoxaline Derivatives Mehdi Bakavoli, Hosein Eshghi, Hamid Azizollahi, Sattar Saberi, and Marziyeh Akbarzadeh. Kiran Ga*, Laxminarayana Eb, Thirumala Chary Mc and Ravinder Ma. BibTeX @MISC{Alinezhad_anefficient, author = {Heshmatollah Alinezhad and Mahmood Tajbakhsh and Mohammad Norouzi and Saeed Baghery}, title = {An Efficient and Green Protocol for the Synthesis of 1,5-benzodiazepine and Quinoxaline Derivatives Using Protic Pyridinium Ionic Liquid as a Catalyst}, year = {}}. Phospho sulfonic acid (PSA) synthesized as an environmentally safe and efficient solid acid catalyst, and it used for the synthesis of several 2-disubstituted benzimidazoles, 2-substituted benzoxazoles, and 2-substituted quinoxalines in ethanol as a green solvent at ambient temperature is described. et al evaluated for in vitro efficacies of the 1,4-di-N-oxide quinoxaline derivatives against Mycobacterium tuberculosis and has lead to the discovery of a derivative with in vivo efficacy in the mouse model of tuberculosis24. 65 , 7129 (2009). Synthesis and ultrafast excited-state dynamics of zinc and palladium triply fused diporphyrins. Conclusions In conclusion, a reliable, rapid and eco-friendly method for synthesis of quinoxalines has been. AB - Cupric sulfate pentahydrate is an efficient catalyst for a one-pot synthesis of quinoxaline derivatives. Autino , 1 Nancy Quaranta , 2 Patricia G. ir Abstract Efficient syntheses of quinoxalines from the reaction of a-hydroxy ketones and o- phenylenediamine in acetic acid via two methods, a thermal procedure. Pawara,* a Organic Chemistry Synthesis Lab. new, efficient and versatile procedure for the preparation of this class of compounds. The substrate was treated with TBN and the additive tetra-n-butylam-monium bromide (TBAB) in MeCN at 608C. Quinoxaline has also been synthesized by the chemical reaction of phenylene diamine and different substituted phenacyl bromides via solid phase [49, 50], synthesis by using different catalyst like 1,4-diazabicyclo [2,2,2]octane, trimethylsilyl chloride, perchloric acid supported on silica, KF-alumina, β-cyclodextrin. (Scheme 1) Scheme 1. By using of this synthesis method of these compounds based on condensation of Aryl-1,2-di amine with 1,2-di carbonyl in the Acidic condition, some new compounds was obtained from Quinoxaline family that for the first time some new catalysts was used for increasing of efficiency and reducing of process time. Present synthesis complies with principle of Green chemistry. Read "Efficient Synthesis of Quinoxaline Derivatives by Selective Modification of 3‐Chloro‐6‐fluoroquinoxalin‐2(1 H )‐one 4‐Oxide, European Journal of Organic Chemistry" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. SiO2 and H3PW12O40 in high yields and short reaction times, and at room temperature is introduced. The readily available and polyfunctionalized 3‐chloro‐6‐fluoroquinoxalin‐2(1H)‐one 4‐oxide, derived from the efficient one‐step annulation reaction of 1,1,2‐trichloro‐2‐nitroethene with 4‐fluoroaniline, was selectively modified at the chloronitrone and the amide units, leading to more than 30 new quinoxaline derivatives with a unique substitution pattern in good to. An efficient and rapid method has been developed for the synthesis of quinoxalines via condensation of 1,2- diketones and 1,2-diamines using RuCl 3. An efficient and clean synthesis of thiophenyl thiazole depended novel triazolo[4IP-a]quinoxaline derivatives Haresh G. Pharm research project based on lead modification and testing for its biological activity. We report a suitable quinoxaline synthesis using molybdophosphovanadates supported on commercial alumina cylinders as catalysts. NH2 NH2 O O + EtOH. Tetrahedron Letters Tetrahedron Letters 46 (2005) 7183–7186 An efficient protocol for the synthesis of quinoxaline derivatives at room temperature using molecular iodine as the catalyst Rajesh S. Bhosale,a Swapnil R. Very recently we have developed a convenient and efficient procedure for synthesis of quinoxaline derivatives using cupric sulfate pentahydrate as catalyst. Ligand efficiency indexes and predicted toxicity analysis revealed an excellent intrinsic quality of 1. Firstly, the polyspecificity at the B-ring position as a consequence of the high efficiency of both newly-synthesized quinoxaline- and 1-naphthyl-derivatives was shown by comparison to that of 3,4-methylenedioxyphenyl- and 2-naphthyl-containing chalcones recently characterized. , 19 (2), 264–269, 2012. Catalysis Communications 9 1143-1147. photosensitizers to broaden the active area of diaryliodonium salts. efficient, novel, safe, simple and catalyst-free method for the preparation of quinoxaline derivatives is desirable. 4h2o as an efficient, mild and reusable catalyst Mar 1, 2009 · Journal of The Iranian Chemical Society 1. V and Subba Narayana Kanchana Department of Chemistry, Sri Krishnadevaraya University, Anantapur, AP, India _____ ABSTRACT Quinoxaline derivatives have several pharmaceutical applications. Vázquez , 3 and Gustavo P. The yields were ranged in 86. Lowering the temperature to. Efficient syntheses of quinoxalines from the reaction of α-hydroxy ketones and o- phenylenediamine in acetic acid via two methods, a thermal procedure and by microwave irradiation, are described. synthetic organic chemistry, there has been tremendous interest in developing efficient methods for the synthesis of quinoxalines. Efficient Synthesis of Quinoxaline Derivatives by Selective Modification of 3‐Chloro‐6‐fluoroquinoxalin‐2(1H)‐one 4‐Oxide. Toggle navigation. Silica Boron Sulfonic Acid as a New and Efficient Catalyst for the Green Synthesis of Quinoxaline Derivatives at Room Temperature. Compared with the classical synthetic method, this new method. Autino and Nancy Quaranta and Patricia G. Using this method, quinoxaline derivatives as biologically interesting compounds are produced in high to excellent yields and short reaction times. Sajjadifar H. مشخصات نویسندگان مقاله ZnO nanoparticles: An Efficient Nanocatalyst for the synthesis of quinoxaline in solvent Free Condition B Sadeghi - Department of Chemistry, Islamic Azad University, Yazd Branch. Pawara,* a Organic Chemistry Synthesis Lab. - Up-scaling of the process developed in the lab to pilot plant and the desired quality and yield of the product. Box 76169-133 E-mail: [email protected] Autino , 1 Nancy Quaranta , 2 Patricia G. Bhusareb and Rajendra P. Derivatives of quinoxaline prepared from cinnamils NH2 A NH2 B O HO O HO RT N H H A N B O O + Grinding Scheme 3 One-pot efficient green synthesis for derivatives of quinoxaline Quinoxaline derivative metal complexes: Spectrophotometric study of Co(II) and Ni(II) complexes with quinoxaline-2,3-dithiol has been reported by Ayres et al 23. synthesis of 1,5-benzodiazepine (4) and quinoxaline (5) washed with water (5 mL) and extracted with derivatives, we herein report an expeditious and efficient dichloromethane (10 mL). Synthesis and Biological Evaluation of Quinoxaline Derivatives January 2015 - January 2015 B. synthesis of quinoxaline derivatives via condensation of aryl-1,2-diamines with 1,2-diketones using (nh4)6mo7o24. The yields were ranged in 86. well as being important in human health and as receptor antagonists. An efficient and inexpensive sulfated polyborate catalyst was applied for the rapid synthesis of quinoxaline derivatives from various substituted o-phenylenediamines and 1,2-diketones/ α-hydroxy. Easily synthesized1-methyl-3- (2-oxyethyl) -1H-imidazol-3-ium-borate sulfonic acid {[MOEI] -BSA} as a novel catalyst efficiently promoted the synthesis of quinoxaline derivatives via condensation of various diamines with 1, 2-dicarbonyl compounds at room temperature conditions in ethanol. Quinoxaline as a potent heterocyclic… 22 11. The unprecedented sensitivity and partial selectivity of quinoxaline-walled thioether-legged deep cavitand functionalized multiwall carbon nanotubes toward traces of benzene vapors are presented. Very recently we have developed a convenient and efficient procedure for synthesis of quinoxaline derivatives using cupric sulfate pentahydrate as catalyst. A Green and Efficient Protocol for the Synthesis of Quinoxaline, Benzoxazole and Benzimidazole Derivatives Using Heteropolyanion-Based Ionic Liquids: As a Recyclable Solid Catalyst. Journal of Industrial and Engineering Chemistry. 12 3 IBX , HOAc RT R R O O N N R1 R R NH2NH2R1 + Scheme 1 Results and Discussion Very recently we have developed a convenient and efficient procedure for synthesis of quinoxaline derivatives using cupric sulfate pentahydrate as catalyst. Journal of Physical Chemistry C , 113 (4), 1589-1595. The condensation of 1,2-diamines with 1,2-diketones using lithium bromide (LiBr) in H 2O/EtOH as a green reaction media at room temperature affords the title compounds in high to excellent yields and in short reaction times. Homogeneous hydrogenation of carbon dioxide to methanol Yu-Nong Li, Ran Ma, Liang-Nian He and Zhen-Feng Diao Catal. A simple and efficient approach for the synthesis of thiophenyl thiazole based triazolo [4,3-a] quinoxaline derivatives is described. The objective of present research work is to provide green technique for synthesis of quinoxaline derivative. A simple, highly efficient and green procedure for the condensation of aryl and alkyl 1,2-diamines with α-diketones in the presence of catalytic amount of boron sulfonic acid (BSA) and silica trimethyl borat (STMB) and silica triisopropyl borate (STIPB), as two novel heterogeneous Lewis acid catalysts at room temperature, is described. Pharm research project based on lead modification and testing for its biological activity. This "Cited by" count includes citations to the following articles in Scholar. Oskooie, Majid M. An efficient one-pot synthesis of tetrahydrobenzo [a] xanthene-11-one and diazabenzo [a] anthracene-9, 11-dione derivatives under solvent free condition. ", abstract = "Heterocyclic amines (HCAs) are mutagenic compounds present in cooked meat and fish, and some of them are known to be carcinogenic. organic synthesis, and we present an efficient and practical protocol, which rapidly synthesized 5,6-dihydroindolo[1,2-a]quinoxaline derivatives by copper-catalyzed intramolecular N-arylation with good to excellent yields. The condensation of 1,2-diamines with 1,2-diketones using lithium bromide (LiBr) in H 2O/EtOH as a green reaction media at room temperature affords the title compounds in high to excellent yields and in short reaction times. Page 280 One-pot and efficient protocol for synthesis of quinoxaline derivatives Mohammad Reza Islami* and Zahra Hassani Department of Chemistry, Shahid Bahonar University, Kerman, Iran P. A green and efficient synthesis of quinoxaline derivatives catalyzed by 1- n -butyl-3-methylimmidazolium tetrafluoroborate The room temperature ionic liquid 1- n -butyl-3-methylimmidazolium tetrafluoroborate ([bmim]BF 4 ) was used to promote the synthesis of quinoxaline derivatives under grinding condition. Journal of Industrial and Engineering Chemistry. With the development of organic optoelectronic materials and bioimaging technology, to exploit organic luminescent materials with high luminescent efficiency in aggregation-state has become a research hotspot. We describe an efficient and clean method for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones catalyzed by sodium tetrachloroaurate(III) dihydrate under mild conditions. The method is very convenient and applicable for alkyl as well as aryl amines and phenacyl bromides. A Highly Efficient Bismuth Salts-Catalyzed Route for the Synthesis of α-Aminophosphonates: Highly Efficient and Reusable Copper-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles with Aryl Halides: A green and efficient synthesis of quinoxaline derivatives catalyzed by 1-n-butyl-3-methylimmidazolium tetrafluoroborate. Isopropylidenation of 4-chloro-4-deoxy-α-d-galactose with 2,2-dimethoxypropane, followed by selective hydrolysis, afforded 2,3-O-isopropylidene-4-chloro-4-deoxy-d-galactose di-methyl acetal (3) as a sole product. 10 Additionally synthesis of quinoxalines by using solid-phase synthesis,11 β-cyclodextrin (β-CD),12 DABCO13 oxidation trapping of α-hydroxy ketones with 1,2 diamines. The rearrangement represents a facile approach to medicinally important biheterocyclic compounds. The principle target of my thesis is to develop new and efficient methodologies for sustainable construction of C-C and C-N bonds using renewable alcohols as coupling partner. Huang et al found Keggin type heteropolyacids to be an efficient and reusable catalyst for the synthesis of biologically active quinoxaline derivatives from the condensation of 1,2-diamine with 1,2-dicarbonyl compounds in excellent yields in water. The versatility of the synthetic approach also enabled the design and synthesis of ten analogues, which provided the first structure-activity relationship study for this class of compounds. Romanelli 3 , *. Highly efficient and simple methods have been described for the synthesis with excellent yields (95-98%). Synthesis and antimicrobial activity of some new quinoxaline derivatives Subba Rami Reddy SR*, Suryanarayana Rao. - Serve as the point of contact for synthesis efforts across the Center. Bhusareb and Rajendra P. Box 76169-133 E-mail: [email protected] The catalyst was shown to be equally effective for the synthesis of quinoxalines from o -phenylenediamine and α-bromo ketones under the similar reaction conditions. These are useful as intermediates for many target molecules in organic synthesis and also as synthons. As a continuation of our research and with the aim of obtaining new antibacterial agents which can improve the current chemotherapeutic antibacterial treatments, a series of quinoxaline-1,4-di-N-oxide derivatives were synthesized and evaluated for antibacterial activity against bacterial growing in macrophages in vitro. 35 In this article we report the synthesis of quinoxaline derivatives in the presence of IBX. Efficient Synthesis of Quinoxaline Derivatives Catalyzed by p-Toluenesulfonic Acid Under Solvent-Free Conditions. Ruiz and Juan C. Author(s): Seyed Mohammad Vahdat, Saeed Baghery. , & Wang, Z. AB - Cupric sulfate pentahydrate is an efficient catalyst for a one-pot synthesis of quinoxaline derivatives. Quinoxaline-based D-A conjugated polymers for organic solar cells: Probing the effect of quinoxaline side chains and fluorine substitution on the power conversion efficiency. As a continuation of our research and with the aim of obtaining new antibacterial agents which can improve the current chemotherapeutic antibacterial treatments, a series of quinoxaline-1,4-di-N-oxide derivatives were synthesized and evaluated for antibacterial activity against bacterial growing in macrophages in vitro. NH2 NH2 O O + EtOH. Ruiz , 1 Juan C. A highly efficient and facile method has been described for the synthesis of quinoxaline derivatives in good to excellent yields (80-99%) by condensation reaction of heterocyclic as well as aliphatic 1,2-diketones (R 1 COCOR, R 1 = Et, Ph, p -MeC 6. A green synthesis of quinoxaline derivatives & their biological actives. Quinoxaline derivatives have been prepared in good to excellent yields using silica gel as catalyst from various 1,2-diketones and 1,2-diamines under solvent-free conditions for the first time. In this methodology, 3-hydrazinyl-N-(4-(thiophen-2-yl) thiazol-2-yl) quinoxalin-2-amine derivatives treated with various aromatic aldehyde to form Schiff base which on treatment with iodobenzene diacetate in dichloromethane at room temperature to furnish title. Simple and efficient synthetic procedures for the preparation of quinoxaline, pyrazine, pyridopyrazine, and benzoxazin-2-one derivatives were developed. Heravi et al has carried out the synthesis of quinoxalines and quinoxaline-2,3-diones as NMDA receptor antagonist in the presence of o-Iodoxybenzoic acid (IBX) at room temperature. In general, this method affords the. Molecules 2015, 20,. , 2-(6H-indolo[2,3-b]quinoxalin-yl)-6H- indolo[2,3-b] quinoxaline 1a have been synthesized by enhanced Fittig method. The device containing 2,3-bis(3,6-dimethoxy-9H-carbazol-9-yl)quinoxaline, as an emitter showed the external quantum efficiency of 10. -Custom synthesis & contract manufacturing process for the key intermediates that are part of NCE of drug discovery program. Therefore, the development of simple, rapid, and efficient procedures for the synthesis of quinoxaline derivatives is still needed. The catalyst is efficient and recoverable,but the reaction requires an oxygen atmosphere,and the catalytic efficiency decreases significantly upon reuse. Sajjadifar H. A one-pot catalyst-free synthesis of functionalized pyrrolo[1,2-a]quinoxaline derivatives from benzene-1,2-diamine, acetylenedicarboxylates and ethyl bromopyruvate The catalyst-free multicomponent reaction of 1,2-diaminobenzene, dialkyl acetylenedicarboxylates, and ethyl bromopyruvate forms pyrrolo[1,2-a]quinoxaline derivatives in good yields. The present invention concerns compounds derived from quinoline and quinoxaline, their preparation and their uses, particularly in the field of therapeutics and vaccines or for developing active compounds. Romanelli 3 , *. A highly efficient and versatile method for the synthesis of quinoxaline derivatives with two benzimidazole fragments have been developed on the basis of the ring contraction of 3-(benzimidazo-2-yl)quinoxalin-2(1 H )-one with 1,2-diaminobenzene and its various types of substituted and condensed derivatives. A precursor strategy for the synthesis of low band-gap polymers: An efficient route to a series of near-infrared electrochromic polymers. A highly efficient and facile method has been described for the synthesis of quinoxaline derivatives in good to excellent yields (80-99%) by condensation reaction of heterocyclic as well as aliphatic 1,2-diketones (R 1 COCOR, R 1 = Et, Ph, p -MeC 6. Quinoxaline has also been synthesized by the chemical reaction of phenylene diamine and different substituted phenacyl bromides via solid phase [49, 50], synthesis by using different catalyst like 1,4-diazabicyclo [2,2,2]octane, trimethylsilyl chloride, perchloric acid supported on silica, KF-alumina, β-cyclodextrin. This will be discussed later in the chapter. The procedure presented is operationally simple, practical and green. Quinoxaline derivatives are well known in the pharmaceutical industry and have. An Efficient and Recyclable Nanoparticle-Supported Cobalt Catalyst for Quinoxaline Synthesis. Sign In Join Now. Synthesis and design of novel pteridine, quinoxaline and boron compounds with higher biological activity in Drug Discovery processed under industry methodology and SOP operation. 12 3 IBX , HOAc RT R R O O N N R1 R R NH2NH2R1 + Scheme 1 Results and Discussion Very recently we have developed a convenient and efficient procedure for synthesis of quinoxaline derivatives using cupric sulfate pentahydrate as catalyst. Isopropylidenation of 4-chloro-4-deoxy-α-d-galactose with 2,2-dimethoxypropane, followed by selective hydrolysis, afforded 2,3-O-isopropylidene-4-chloro-4-deoxy-d-galactose di-methyl acetal (3) as a sole product. have investigated the synthesis of quinoxalines in the presence of heteropoly acid at room temperature. Abstract A very simple, green and efficient protocol is developed in which zinc chloride-exchanged K10-montmorillonite (clayzic) is employed as a Lewis acid catalyst in aqueous media at room temperature for the synthesis of various benzimidazoles and quinoxalines from carbonyl compounds and o -phenylenediamine. Synthesis of Quinoxaline Derivatives using Sulfonic Acid Functionalized Imidazolium Salts as Highly Efficient and Reusable Bronsted Acidic Ionic Liquids Catalysts under Solvent-free Conditions SAMI SAJJADIFAR*, ESHAGH REZAEE NEZHAD and EHSAN KHOSRAVANI Department of Chemistry, Payame Noor University, P O Box 19395-4697, Tehran, Iran. Quinoxaline-based D-A conjugated polymers for organic solar cells: Probing the effect of quinoxaline side chains and fluorine substitution on the power conversion efficiency. In general, this method affords the. C8H6N2 Bicyclic organic base; colorless powder, soluble in water and organic solvents; melts at 30°C; used in organic synthesis. a simple and efficient microwave-assisted synthesis of quinoxaline and spiro-indole derivatives in xylene Shivam Bajpai 1 , Sundaram Singh 2 and Vandana srivastava 3 Research Scholar, Department of Chemistry, IIT-BHU, Varanasi, India. magnetically separable cufe2o4 nanoparticles: an efficient catalyst for the synthesis of quinoxaline derivatives in tap-water under sonication A simple and rapid synthetic methodology has been explored exhibiting the use of a magnetically separable copper ferrite (CuFe 2 O 4 ) nanocatalyst in water for the construction of medicinally privileged. Burguete A, Pontiki E, Hadjipavlou-Litina D, Ancizu S, Villar R, Solano B, Moreno E, Torres E, Pérez S, Aldana I, Monge A (2011) Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents. 2013,5(4) 2047 As previously showed, [Dsim]Cl, [Msim]PF6 and [Msim]BF4 were highly efficient and general for the synthesis of the quinoxaline derivatives. Sajjadifar H. Synthesis and Characterization of 5,6 substituted, 2,3diaryl, Quinoxaline 1,4-di- N-Oxide derivatives and 7-substituted-2,3-diphenyl pyrido[3,2-b]pyrazine derivatives & Investigations of their Anticancer Activity beside Microbial. Andriamitantsoa, a Jingjing Wang, a Wenjun Dong, a Hongyi Gao, a Ge Wang *a a Beijing Key Laboratory of Function Materials for Molecule & Structure Construction, School. model substrate and the efficiency of formation of quinoxaline 3aa was examined. An efficient and facile synthesis of quinoxaline derivatives catalyzed by KHSO 4 at room temperature Hossein A. Simple and efficient synthetic procedures for the preparation of quinoxaline, pyrazine, pyridopyrazine, and benzoxazin-2-one derivatives were developed. Homogeneous hydrogenation of carbon dioxide to methanol Yu-Nong Li, Ran Ma, Liang-Nian He and Zhen-Feng Diao Catal. 2005 , 46 , 7183–7186. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones. et al evaluated for in vitro efficacies of the 1,4-di-N-oxide quinoxaline derivatives against Mycobacterium tuberculosis and has lead to the discovery of a derivative with in vivo efficacy in the mouse model of tuberculosis24. We describe an efficient and clean method for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones catalyzed by sodium tetrachloroaurate(III) dihydrate under mild conditions. Comptes Rendus Chimie - In Press. com Abstract. Cupric sulfate pentahydrate is an efficient catalyst for a one-pot synthesis of quinoxaline derivatives. An efficient protocol for the synthesis of quinoxaline derivatives at room temperature using molecular iodine as the catalyst. , 2013, 3, 2214-2220 DOI: 10. In the synthesis, the reaction of 1,2-phenylenediamines and phenacyl bromide were carried out using pyridine as a catalyst in THF at room temperature to give quinoxalines. Therefore, the development of simple, rapid, and efficient procedures for the synthesis of quinoxaline derivatives is still needed. Abstract An efficient and practical protocol has been developed to synthesize 5,6-dihydroindolo[1,2-a]quinoxaline derivatives by CuI-catalyzed intramolecular N-arylation under microwave irradiation. Highly efficient and simple methods have been described in this manuscript for the synthesis with competent yields. JAGANNADHAM and SUMANGALA RAO Research Centre, Department of Chemistry Chaitanya PG College, Warangal-506 001, India [email protected] Prasanna , B. Quinoxaline-based D-A conjugated polymers for organic solar cells: Probing the effect of quinoxaline side chains and fluorine substitution on the power conversion efficiency. The resulting (2-nitrophenyl)-4,5-diphenyl-1h-imidazole from the reaction of benzil and different 2-nitrobenzaldehyde, reduction of nitro group and then cyclization reaction with carbon disulfide (cs2) list green synthesis of quinoxaline derivatives of citation(s) zwitterionic imidazolium salt of [moei] -bsa: in this thesis statement builder. The catalyst was shown to be equally effective for the synthesis of quinoxalines from o -phenylenediamine and α-bromo ketones under the similar reaction conditions. Romanelli and La Plata Baan}, title = {The cientificWorldJOURNAL Research Article An Efficient Protocol for the Synthesis of Quinoxaline Derivatives at Room Temperature Using Recyclable}, year = {2011}}. The substrate was treated with TBN and the additive tetra-n-butylam-monium bromide (TBAB) in MeCN at 608C. The procedure presented is operationally simple, practical and green. Via a ruthenium-catalyzed hydrogen transfer strategy, we have demonstrated a one-pot method for efficient synthesis of quinoxalines from 2-nitroanilines and biomass-derived vicinal diols for the. Ruiz , 1 Juan C. In addition, the electronic properties of the versatile starting compound were computed. Read "Efficient Synthesis of Quinoxaline Derivatives by Selective Modification of 3‐Chloro‐6‐fluoroquinoxalin‐2(1 H )‐one 4‐Oxide, European Journal of Organic Chemistry" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Vázquez and Gustavo P. SO3H-functionalized metal organic frameworks: an efficient heterogeneous catalyst for the synthesis of quinoxaline and derivatives RADOELIZO S. for the Convenient and Efficient Synthesis of Allyl. This new strategy has several advantages, such as excellent yield, mild reaction conditions, short duration of reaction time, low cost, simple experimental as well as isolation procedures, and. Our research toward the expansion of efficient and environmentally benign synthetis methodologies using eco-friendly conditions[30], we report here the synthesis of quinoxalines from o-phenylenediamine and various α-diketones in the presence. The readily available and polyfunctionalized 3‐chloro‐6‐fluoroquinoxalin‐2(1H)‐one 4‐oxide, derived from the efficient one‐step annulation reaction of 1,1,2‐trichloro‐2‐nitroethene with 4‐fluoroaniline, was selectively modified at the chloronitrone and the amide units, leading to more than 30 new quinoxaline derivatives with a unique substitution pattern in good to excellent yields.